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KMID : 0861020220370050063
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Korea Journal of Herbology
2022 Volume.37 No. 5 p.63 ~ p.74
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Anti-inflammatory effect of Uncariae Ramulus et Uncus on alcohol-induced gastritis
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Lee Jin-A.
Shin Mi-Rae
Park Hae-Jin
Roh Seong-Soo
Lee Tae-Jong
Kim Jin-Young
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Abstract
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Objective : Gastritis refers to an inflammatory disease of the gastric mucosa. Alcohol is one of the main aggression
factors, causing bleeding and inflammation in the gastric mucosa and it is known to not only increase lipid peroxide
levels, but also deplete key antioxidant factors. The purpose of this study was to determine the effect of Uncariae
Ramulus et Uncus water extract (URW) in alcohol-induced gastritis.
Methods : The total polyphenol and flavonoid contents of URW were confirmed through an in vitro experiment. Also,
2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical
scavenging activity and ferric reducing antioxidant power (FRAP) activity were confirmed. For in vivo experiments,
mice were divided into 4 groups (n=8). Also, 1 hr after oral administration of each drug, 50% ethanol was orally
administered to induce gastritis.
Results : As a result of in vitro experiments, URW showed excellent antioxidant activity. In alcohol-induced gastritis, URW alleviated the damage to the gastric mucosa caused by alcohol. Also, URW decreased reactive oxygen species
(ROS) and malondialdehyde (MDA) levels in serum and gastric tissues, and significantly decreased the expression of
NADPH oxidases in gastric tissues. In addition, it significantly modulated the nuclear factor erythroid-derived 2-related
factor 2 (Nrf2) and nuclear factor-κ B p65 (NF-κB) pathways as well as significantly increased the expression of
anti-inflammatory proteins.
Conclusions : These results suggest that URW not only reduces oxidative stress through excellent antioxidant activity
but also relieves gastric mucosal inflammation as a regulator of Nrf2 and NF-κB pathways. 1
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KEYWORD
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Uncariae Ramulus et Uncus, gastritis, antioxidant, oxidative stress, inflammation
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